Xeon E5335 's Advantages
Lower TDP (80W vs 205W)
Intel Xeon Platinum 8280M 's Advantages
Released 12 years and 1 months late
Higher specification of memory (DDR4-2933 vs DDR3
Depends on motherboard)
Higher base frequency (2.7GHz vs 2GHz)
More modern manufacturing process (14nm vs 65nm)