Opteron 8218 (F3) 's Advantages
Lower TDP (95W vs 240W)
AMD EPYC 7F72 's Advantages
Released 13 years and 8 months late
Higher specification of memory (DDR4-3200 vs DDR2-667)
Newer PCIe version (4 vs 1)
Higher base frequency (3.2GHz vs 2.6GHz)
More modern manufacturing process (7nm vs 90nm)