Opteron 6386 SE 's Advantages
Higher base frequency (2.8GHz vs 2.1GHz)
Lower TDP (140W vs 250W)
Intel Xeon Platinum 9221 's Advantages
Released 6 years and 5 months late
Higher specification of memory (DDR4-2933 vs DDR3)
Newer PCIe version (3 vs 2)
Larger L3 cache size (71.5MB vs 8MB)