Opteron 6380 's Advantages
Lower TDP (115W vs 190W)
AMD EPYC 7343 's Advantages
Released 8 years and 4 months late
Higher specification of memory (DDR4-3200 vs DDR3)
Newer PCIe version (4 vs 2)
Higher base frequency (3.2GHz vs 2.5GHz)
Larger L3 cache size (128MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)