Opteron 6378 's Advantages
Lower TDP (115W vs 280W)
AMD EPYC 7573X 's Advantages
Released 9 years and 4 months late
Higher specification of memory (DDR4-3200 vs DDR3)
Newer PCIe version (4 vs 2)
Higher base frequency (2.8GHz vs 2.4GHz)
Larger L3 cache size (768MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)