Opteron 6281 's Advantages
Higher base frequency (2.5GHz vs 2.2GHz)
Lower TDP (130W vs 180W)
AMD EPYC 7601 's Advantages
Released 5 years and 1 months late
Higher specification of memory (2666 vs 1600)
Newer PCIe version (3 vs 2)
Larger L3 cache size (64MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)