Opteron 6272 's Advantages
Lower TDP (115W vs 170W)
AMD EPYC 7301 's Advantages
Released 5 years and 7 months late
Higher specification of memory (DDR4-2666 vs DDR3)
Newer PCIe version (3 vs 2)
Higher base frequency (2.2GHz vs 2.1GHz)
Larger L3 cache size (64MB vs 16MB)
More modern manufacturing process (14nm vs 32nm)