Opteron 4376 HE 's Advantages
Higher base frequency (2.6GHz vs 2.5GHz)
Lower TDP (65W vs 170W)
AMD EPYC 7261 's Advantages
Released 5 years and 6 months late
Higher specification of memory (DDR4-2666 vs DDR3)
Larger L3 cache size (32MB vs 8MB)
More modern manufacturing process (14nm vs 32nm)