Intel Xeon Gold 6421N 's Advantages
Released 9 years and 4 months late
Higher specification of memory (DDR5-4400 vs DDR3)
Newer PCIe version (5 vs 3)
Larger L3 cache size (60MB vs 15MB)
More modern manufacturing process (10nm vs 22nm)
Intel Xeon E5 2643 v2 's Advantages
Higher base frequency (3.5GHz vs 1.8GHz)
Lower TDP (130W vs 185W)