Intel Xeon E3 1280 's Advantages
Higher base frequency (3.5GHz vs 2.1GHz)
Lower TDP (95W vs 165W)
Intel Xeon Gold 5318S 's Advantages
Released 10 years late
Higher specification of memory (DDR4-2933 vs DDR3)
Newer PCIe version (4 vs 3)
Larger L3 cache size (36MB vs 8MB)
More modern manufacturing process (10nm vs 32nm)