AMD EPYC 7643P 's Advantages
Released 11 years and 4 months late
Higher specification of memory (3200 vs 1600)
Newer PCIe version (4 vs 2)
Larger L3 cache size (256MB vs 8MB)
More modern manufacturing process (7nm vs 32nm)
Opteron 6281 's Advantages
Higher base frequency (2.5GHz vs 2.3GHz)
Lower TDP (130W vs 225W)