AMD EPYC 7251 's Advantages
Released 9 years and 10 months late
Higher specification of memory (DDR4-2400 vs DDR2-667)
Newer PCIe version (3 vs 1)
More modern manufacturing process (14nm vs 90nm)
Opteron 8222 's Advantages
Higher base frequency (3GHz vs 2.1GHz)
Lower TDP (95W vs 120W)