Intel Xeon E 2378 's Advantages
Higher base frequency (2.6GHz vs 2GHz)
Lower TDP (65W vs 150W)
Intel Xeon Gold 5416S 's Advantages
Released 1 years and 4 months late
Higher specification of memory (DDR5-4400 vs DDR4-3200)
Newer PCIe version (5 vs 4)
Larger L3 cache size (30MB vs 16MB)
More modern manufacturing process (10nm vs 14nm)